So far as Colorado and Wyoming go:
Maybe hit Colorado the first week and then Wyoming and back home.
Come into Southeast Colorado on your way to the Highway of Legends
Colorado Byways . Then on to the Royal Gorge or Pikes Peak or both.
More Colorado Byways Then take the scenic route around Denver. Then on into Estes Park, Steamboat Springs and Walden and on into Wyoming near Saratoga and Encampment.
There is plenty to see in and around Jackson. Come into Jackson from the south – Rock Springs, Wyoming (I-80 & Highway 191), if at night be wary of game crossing the road. If the road is not dry do not get on it…Oil field/Gas field trucks own that road all the way to Pinedale, Wyoming. Then the road has a wonderful view of the Wind River Range on your right until you drive right into the range on up into Jackson and the Tetons. Yellowstone is just north and all the park should be open in May. There is a Buffalo Bill museum in Cody, Wyoming (not far). On the way back you could go across the northern part of Wyoming and see the vast difference from the Southern part. Possibly, hit Devils Tower just north out of Moorcroft, Wyoming and maybe some or all of these places
Wyoming Stuff More Wyoming Stuff. Then onto South Dakota and Mount Rushmore and back home.
I don’t know if you can fit all of that in two weeks but, that is a possible start. Hope this helps. Good Luck.