It is very simple really. I assume that you have a prom style ECM seeing how you are going to use the ROMULATOR.If your car is a 86 and up that uses a GM MEMCAL which is the large blue prom. You will need a adapter board. Such as a Moates part number G1 adapter. See Craig Moates website at:
http://www.moates.net
Using this adapter board allows you to plug in your GM memcal and it provides a socket to land the ROMULATOR connector to. Then you start up Tuner Cats RT Tuner software, load your BIN file into RT Tuner and then syncronize the program to the ROMULATOR. Thats about it once, it syncs it has loaded your file to the ROMULATOR and your engine will be running from the ROMULATOR memory.
During a test run, you can make changes to any parameter, in the BIN file that is editable within TC. When making a change in the constants table, you make the change and click on "update" which of course updates the ROMULATOR memory of your change.
Once you are done, save the file and burn a chip. Remove the ROMULATOR connector and plug in your newly burned chip and you are done. That is about it, really simple isn't it? :)