Deadening the doors will improve midbass response for sure. Properly tuning your sub and its crossover points/slopes and matching it well with the midbass is key to getting good "up front" midbass. I am most likely going to be at 80hz on the midbass 24db slope in my truck install with the 720's. 80hz 24 or 18db on the sub. Really getting it dialed in comes down to what processing you have. Time alignment can make a huge difference in a car.
The Pioneers need some power so bridging them is a good idea.
Might be worth looking into Cowboys heat/insulation kit, it helped with my install for some noise reduction (coupled with some liquid
deadener).
As for the tweet placement, IMO it all depends on how you drive. With my left arm up I block 90% of the sound from the drivers side tweet, which is incredibly annoying to me (mounted in the door pulls). Moving my tweets up into the pillars very soon once I make time to experiment more with the exact placement in my 3 way setup. However in a 2 way I would probably recommend mounting the tweets as close to the grill and as high up as possible in the stock location, while keeping it unblocked, aimed as best you can to "crossfire" in the cabin. Experiment a bit with what sounds best to your ear before you commit to a location however. They may sound better "bounced" a bit and fired into the windshield vs back towards the passengers. And IMO at the end of the day set it up for what sounds best to you in the drivers seat, since it is your car so you should get the most enjoyment!
Fej